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Flos lonicerae and Rhizoma Cimicifugae were found to be able to alter -1 PRF efficiency. They diminished the inhibition zone and changed the phenotype of T158c/S14a (Fig1, Fig2). Furthermore, the extract of 8g Flos lonicerae by 50ml pure water could totally clear the inhibition zone. These results illustrated that Flos lonicerae and Rhizoma Cimicifugae could be natural anti-viral herb drugs whose potential target was -1 PRF RNA viruses. MEDI 76 Total synthesis of carbocyclic sinefungin Xueqiang Yin1, Guo-xia Zhao2, and Stewart W.

We synthesized the [18F] labeled BMS-354825 analog. The analog potently inhibits the tyrosine kinase activity of imatinib-resistant ABL mutants, similar to BMS-354825. PET imaging with [18F] of a BMS-354825 analog could help to identify imatinib-resistant CML patients. The methods of cold synthesis, radiolabeling and in vivo tissue distribution in rats are described. MEDI 105 Synthesis of [124I]Iodo-ABT-737, a PET imageable tracer for BCl-2 expression in tumors Dongmei Han1, Liwei Guo1, David S Maxwell1, David J.

Brown3, Robert Harvey3, Phiroze Sethna3, Qin Zhang3, Pamela Golden4, and Shiping Xie5. (1) Department of Medicinal Chemistry, GlaxoSmithKline, Five Moore Drive, Research Triangle Park, NC 27709, (2) Medicines Research Centre, GlaxoSmithKline, (3) Department of Oncogenic and Emerging Viruses, GlaxoSmithKline, (4) Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, (5) Chemical Development, GlaxoSmithKline Human papillomaviruses (HPVs) are small DNA viruses that infect the genital mucosa, and are considered the most common sexually transmitted disease throughout the world.

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Abstracts-233rd ACS National Meeting by ACS

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